COPD publications
This section provides links to publications that will help you expand your knowledge about COPD and gain access to additional information that you may find useful in your clinic.
Unless otherwise indicated, Nycomed neither affiliates with nor endorses any of the following publications.
The following lists of publications are not intended to be all-inclusive, but are a representative sampling of key published data in COPD.
COPD - The burden of disease
COPD patients with symptoms of chronic bronchitis/chronic cough and sputum are at more risk of COPD exacerbations and mortality
- Burgel PR, Nesme-Meyer P, Chanez P, et al. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest 2009;135:975-982. http://www.ncbi.nlm.nih.gov/pubmed/19017866.
- Guerra S, Sherrill DL, Venker C, et al. Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. Thorax 2009;64;894-900. http://www.ncbi.nlm.nih.gov/pubmed/19581277.
- Ekberg-Aronsson M, Pehrsson K, Nilsson JA, et al. Mortality in GOLD stages of COPD and its dependence on symptoms of chronic bronchitis. Respir Res 2005;6:98. http://www.ncbi.nlm.nih.gov/pubmed/16120227.
- Niewoehner DE, Lokhnygina Y, Rice K, et al. Risk indexes for exacerbations and hospitalizations due to COPD. Chest 2007;131:20-28. http://www.ncbi.nlm.nih.gov/pubmed/17218552.
COPD exacerbations are associated with increases in airway inflammation
- Bhowmik A, Seemungal TA, Sapsford RJ, et al. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax 2000;55:114-120. http://www.ncbi.nlm.nih.gov/pubmed/10639527.
- Papi A, Bellettato CM, Braccioni F, et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med 2006;173:1114–1121. http://www.ncbi.nlm.nih.gov/pubmed/16484677.
- Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994;150:1646–1652. http://www.ncbi.nlm.nih.gov/pubmed/7952628.
- Perera WR, Hurst JR, Wilkinson TM, et al. Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur Respir J 2007;29:527–534. http://www.ncbi.nlm.nih.gov/pubmed/17107990.
Patients with frequent exacerbations have an increased risk of disease progression
- Wedzicha JA & Seemungal TAR. COPD exacerbations: defining their cause and prevention. Lancet 2007;370:786–796. http://www.ncbi.nlm.nih.gov/pubmed/17765528.
- Donaldson GC, Seemungal TAR, Bhowmik A, et al. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002;57:847–852. http://www.ncbi.nlm.nih.gov/pubmed/12324669.
- Seemungal TAR, Donaldson GC, Paul EA, et al. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;151:1418–1422. http://www.ncbi.nlm.nih.gov/pubmed/9603117.
- Groenewegen KH, Schols AMWJ & Wouters EMF. Mortality and mortality related factors after hospitalisation for acute exacerbation of COPD. Chest 2003;124:459–467. http://www.ncbi.nlm.nih.gov/pubmed/12907529.
- Soler-Cataluna JJ, Martinez-Garcia MA, Roman Sanchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005;60:925–931. http://www.ncbi.nlm.nih.gov/pubmed/16055622.
Frequent exacerbations reflect an independent susceptibility phenotype
The underlying inflammation of COPD is different to asthma inflammation
COPD management
Exacerbations - Definition and diagnosis
COPD - A systemic inflammatory disease